Glowing Liquids Shed New Light on Plastic Surgery Procedures
Glow-in-the-dark substances are often used for cheap thrills like eye-popping visuals at raves or invoking spooky atmospheres at Halloween parties, but a recent study suggests they may soon serve a vital role in the medical industry. A newly developed fluorescent nerve detection liquid could bring about a revolution in how doctors approach plastic, reconstructive, and cancer-related surgeries.
Combined research from University of California San Diego’s departments of pharmacology, chemistry, biochemistry, otolaryngology, and the Howard Hughes Medical Institute has yielded an experimental dye system that will help surgeons differentiate between tissue and nerves in future operations. The system utilizes an amino acid activated fluorescent liquid that is injected into the bloodstream. As the solution courses through the veins, it lights up when it comes in contact with the peptides in nerves.
Conclusions from testing the innovative liquid on mice were recently published in the 29th volume of the scientific journal Nature Biotechnology. The UCSD researchers revealed that nerves treated by the fluorescent dye became ten times more visible to the naked eye than without. The solution took two hours to achieve optimal brightness and the heightened visibility was sustained for upwards of eight hours.
Up to this point, surgeons have relied on spotty electromyographic monitoring and generic illustrations of where nerves should lie in the average patient, but the new glowing guides will give doctors a live map of where nerves systems exist without the guesswork. University of California professor and co-author of the paper, Roger Tsien, explained to the Daily Mail, “The analogy I use is that when construction workers are excavating, they need a map showing where the existing underground electrical cables are actually buried, not just old plans of questionable accuracy.”
This new dye may make its biggest impact in cancer detection, as malignant tumors can often be identified by their entanglement with nerves, but plastic and reconstructive surgeries have a lot to gain as well. Accidental nerve transection is a risk of all invasive surgeries and carries consequences such as pain, numbness, weakness, or muscular paralysis. Especially in facelift or rhinoplastyoperations, where surgeons are dealing with nerve-dense facial areas, there is a low but present risk of nerve damage. With fluorescent injections incidences of accidental nerve injury might all but disappear. The study also hints that those with existing nerve damage might benefit from the fluorescent solution’s use in future reconstructive operations.
Researchers found that highlighting by the wonder liquid occurred independently of what scientists call “axonal integrity” of the particular nerve, meaning damaged or severed nerves glow just as brightly as healthy nerves. This would allow surgeons to isolate damaged nerves and mend them without risking further damage from probing around. Similarly, early swelling from infection or unintended trauma could be visually diagnosed by checking for distressed or displaced nerve systems and immediately treated, potentially lowering the incidence of serious complications in all future plastic surgeries.
While the authors of the UCSD study found no toxicity in their new fluorescent solution and numerous potential medical benefits, it may be a few years until human trials are approved. If you’re looking for the safest cosmetic procedures conducted by experienced, pre-screened, and fully-certified doctors in your area, contact us! Our Plastic Surgery Portal team can schedule you a free and informative consultation with one of our esteemed cosmetic specialists in a city near you!
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